100000 - Document - Document and Entity Information
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100010 - Statement - Condensed Balance Sheets (Unaudited)
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100020 - Statement - Condensed Statements of Operations and Comprehensive Loss (Unaudited)
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100030 - Statement - Condensed Statements of Stockholders' Equity (Unaudited)
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100040 - Statement - Condensed Statements of Stockholders' Equity (Unaudited) (Parenthetical)
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100050 - Statement - Condensed Statements of Cash Flows (Unaudited)
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995455 - Disclosure - Organization and Description of the Business
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995465 - Disclosure - Summary of Significant Accounting Policies
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995475 - Disclosure - Balance Sheet Components
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995485 - Disclosure - Commitments and Contingencies
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995495 - Disclosure - Stock-Based Compensation
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995505 - Disclosure - Term Loan
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995515 - Disclosure - Stockholders' Equity
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995525 - Disclosure - Fair Value Measurements
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995535 - Disclosure - Income Taxes
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995545 - Disclosure - Net Loss Per Share
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995555 - Disclosure - Workforce Reduction
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995565 - Disclosure - Segment Reporting
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995575 - Disclosure - Subsequent Event
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995585 - Disclosure - Summary of Significant Accounting Policies (Policies)
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995595 - Disclosure - Balance Sheet Components (Tables)
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995605 - Disclosure - Commitment and Contingencies (Tables)
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995615 - Disclosure - Stock-Based Compensation (Tables)
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995625 - Disclosure - Stockholders' Equity (Tables)
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995635 - Disclosure - Fair Value Measurements (Tables)
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995645 - Disclosure - Net Loss Per Share (Tables)
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995655 - Disclosure - Segment Reporting (Tables)
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995665 - Disclosure - Organization and Description of the Business - Additional Information (Details)
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995675 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Details)
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995685 - Disclosure - Balance Sheet Components - Summary of Property and Equipment, Net (Details)
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995695 - Disclosure - Balance Sheet Components - Additional Information (Details)
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995705 - Disclosure - Balance Sheet Components - Summary of Accrued and Other Current Liabilities (Details)
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995715 - Disclosure - Balance Sheet Components - Summary of Prepaid Expenses and Other Current Assets (Details)
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995725 - Disclosure - Commitments and Contingencies - Additional Information (Details)
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995735 - Disclosure - Commitments and Contingencies - Summary of Operating Lease Activity (Details)
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995745 - Disclosure - Commitments and Contingencies - Summary of Future Minimum Lease Payments Under Operating Leases (Details)
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995755 - Disclosure - Stock-Based Compensation - Additional Information (Details)
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995765 - Disclosure - Commitments and Contingencies - Summary of Future Minimum Lease Payments Under Operating Leases (Details) 2
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995775 - Disclosure - Stock-Based Compensation - Summary of Stock Option Activity (Details)
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995785 - Disclosure - Stock-Based Compensation - Summary of Fair Value of Stock Option Awards (Details)
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995795 - Disclosure - Stock-Based Compensation - Summary of Restricted Stock Activity (Details)
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995805 - Disclosure - Stock-Based Compensation - Summary of Stock-based Compensation (Details)
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995815 - Disclosure - Term Loan - Additional Information (Details)
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995825 - Disclosure - Stockholders' Equity - Additional Information (Details)
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995835 - Disclosure - Stockholders' Equity - Schedule of Common Stock Reserved for Issuance (Details)
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995845 - Disclosure - Fair Value Measurements - Summary of Fair Value of Financial Assets Measured at Fair Value on Recurring Basis (Details)
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995855 - Disclosure - Fair Value Measurements - Additional Information (Details)
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995865 - Disclosure - Income Taxes - Additional Information (Details)
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995875 - Disclosure - Net Loss Per Share - Schedule of Antidilutive Securities Excluded from Computation of Diluted Net Loss Per Share (Details)
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995885 - Disclosure - Workforce Reduction (Additional Information) (Details)
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995895 - Disclosure - Segment Reporting - Additional Information (Details)
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995905 - Disclosure - Segment Reporting - Schedule of Operating Expenses by Function (Details)
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995915 - Disclosure - Subsequent Event - Additional Information (Details)
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Statement [Line Items]
Statement [Line Items]
Debt Instrument, Interest Rate During Period
Interest Rate During Period
Debt Instrument [Axis]
Commitments And Contingencies [Line Items]
Commitments And Contingencies [Line Items]
Commitments and contingencies.
Plan Name
Plan Name [Domain]
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Impairment charges on marketable securities related to other-than-temporary
Impairment Charges On Marketable Securities Related To Other Than Temporary
Impairment charges on marketable securities related to other-than-temporary.
Manufacturing [Member]
Manufacturing.
Manufacturing (pre-commercial)
Debt instrument redemption price of principal amount redeemed.
Debt Instrument Redemption Price Of Principal Amount Redeemed
Redemption of Aggregate Principal Amount
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Fair Value, Recurring and Nonrecurring [Table]
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract]
Other comprehensive loss:
Additional amount available upon satisfaction of certain milestones
Line Of Credit Facility, Capacity Available For Satisfaction Of Certain Milestones
Line of credit facility, capacity available for satisfaction of certain milestones.
Percentage of reduction in workforce.
Percentage of Reduction in Workforce
Percentage of reduction in workforce
At The Market Sales
At The Market Offering Member
At the market offering member.
At-the-market Sales
Number of Operating Segments
Number of operating segment
Share-Based Payment Arrangement, Tranche One [Member]
Share-Based Payment Arrangement, Tranche One
Issuance of common stock upon exercise of stock options and vesting of restricted stock units, shares
Stock Issued During Period Shares Stock Options Exercised And Vesting of Restricted Stock Units
Stock issued during period shares stock options exercised and vesting of restricted stock units.
Available-for-sale marketable securities contractual maturities term
Available For Sale Marketable Securities Contractual Maturities Term
Available-for-sale marketable securities contractual maturities term.
Balance, shares
Balance, shares
Shares, Outstanding
Other Noncash Income (Expense), Total
Other Noncash Income (Expense)
Other
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Axis]
South San Francisco, California
South San Francisco California [Member]
South San Francisco, California.
Maximum Additional Shares Isssuable Value
Maximum Additional Shares Isssuable Value
Maximum additional shares issuable
Level 2
Fair Value, Inputs, Level 2 [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Outstanding Series A and Series B Warrants
Outstanding Series A and Series B Warrants [Member]
Outstanding Series A and Series B warrants.
Number Of Employees Affected Due To Stock Option Repricing
Number of employees affected due to stock option repricing.
Stock option repricing, affected number of employees
Lessee, Operating Lease, Liability, to be Paid, Remainder of Fiscal Year
2025 (nine months remaining)
Commitments and Contingencies
Commitments and Contingencies Disclosure [Text Block]
Restructuring Cost [Table]
Schedule Of Stock By Class [Table]
Stock, Class of Stock [Table]
Proceeds from sales of marketable securities
Proceeds From Sales Of Marketable Securities
Proceeds from sales of marketable securities.
Depreciation, Depletion and Amortization, Total
Depreciation and amortization
Depreciation, Depletion and Amortization
2021 Employee Stock Purchase Plan
Employee Stock [Member]
Common Stock
Equity [Text Block]
Stockholders' Equity
Title and Position [Axis]
Class of Warrant or Right [Axis]
Sale of Stock
Sale of Stock [Domain]
Cash and Cash Equivalents [Domain]
Long-Term Debt, Gross
Funds under loan agreement
Remaining amount available
Line of Credit Facility, Remaining Borrowing Capacity
Grant amount received
Grant Amount Received
Grant amount received.
Entity Central Index Key
Entity Central Index Key
Proceeds from exercises of pre-funded warrants
Proceeds from Exercises of Pre-Funded Warrants
Proceeds from exercise of prefunded warrants
Number of shares underlying repriced option
Number Of Shares Underlying Repriced Option
Number of shares underlying repriced option.
Oustanding Series A And B Warrants [Member]
Oustanding series A and B warrants.
Oustanding Series A and B Warrants
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Cancelled
Debt Instrument, Maturity Date Range, End
Extension Date
Changes in operating assets and liabilities:
Increase (Decrease) in Operating Capital [Abstract]
Debt Instrument, Redemption, Period Five [Member]
Final Tranche
Risk-free interest rate, minimum
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Minimum
Warrant issued to purchase shares of common stock
Warrant issued to purchase shares of common stock.
Warrant Issued to Purchase Shares of Common Stock
Weighted-average remaining lease term
Lessee, Operating Lease, Remaining Lease Term
Organization and description of business.
Organization And Description Of Business [Line Items]
Organization And Description Of Business [Line Items]
Income Statement [Abstract]
Vesting of early exercised stock options
Vesting Of Early Exercised Stock Options
Vesting of early exercised stock options.
Entity Address, State or Province
Entity Address, State or Province
Issuance of common stock pursuant to employee stock purchase plan
Stock Issued During Period, Value, Employee Stock Purchase Plan
Workforce reduction.
Workforce Reduction [Member]
Workforce Reduction
Net loss before income tax expense
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest
Silicon Valley Bank Loan Agreement
Silicon Valley Bank Loan Agreement [Member]
Silicon Valley Bank Loan Agreement.
First Tranche
Debt Instrument, Redemption, Period One [Member]
Maturity date
Line of Credit Facility, Expiration Date
Offering Costs Related to Follow-On Offering and At-The Market-Sales Included in Accounts Payable and Accrued Expenses and Other Current Liabilities
Offering costs related to follow-on offering and at-the market-sales included in accounts payable and accrued expenses and other current liabilities.
Offering costs related to follow-on offering and at-the market-sales included in accounts payable and accrued expenses and other current liabilities
Cover [Abstract]
Subsequent Event [Line Items]
Net loss per share, basic
Earnings Per Share, Basic
Earnings Per Share, Basic, Total
Additional Office and Laboratory Space
Additional Office And Laboratory Space [Member]
Additional office and laboratory space.
Lease, option to extend
Lessee, Operating Lease, Option to Extend
Unrealized Gain
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax
Operating expenses:
Operating Expenses [Abstract]
Total stock-based compensation
Stock-based compensation
Share-Based Payment Arrangement, Expense
Retained Earnings (Accumulated Deficit), Ending Balance
Retained Earnings (Accumulated Deficit), Beginning Balance
Retained Earnings (Accumulated Deficit), Total
Accumulated deficit
Retained Earnings (Accumulated Deficit)
Plan Name
Plan Name [Axis]
Segment Reporting [Abstract]
Shares, Outstanding Ending Balance
Shares, Outstanding Beginning Balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Organization and description of business.
Organization And Description Of Business [Table]
Organization And Description Of Business [Table]
Underwriting discounts and commissions
Underwriting Discounts And Commissions
Underwriting discounts and commissions.
Current assets:
Assets, Current [Abstract]
Common stock reserved for issuance
Common Stock, Capital Shares Reserved for Future Issuance
Net cash used in operating activities
Net Cash Provided by (Used in) Operating Activities
Forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Borrowing capacity of term loans.
Borrowing Capacity of Term Loans
Borrowing capacity of term loans
Stock Issued
Non-cash exercise of stock options
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Accumulated Other Comprehensive Income (Loss), Net of Tax
Accumulated other comprehensive income (loss)
Term of lease
Lessee, Operating Lease, Term of Contract
Lease expiration month and year, end
Lease expiration month and year end
Property, Plant and Equipment, Net, Ending Balance
Property, Plant and Equipment, Net, Beginning Balance
Total property and equipment, net
Property and equipment, net
Property, Plant and Equipment, Net
Lessee, Operating Lease, Liability, to be Paid, Year Four
2029
Cash flows from operating activities:
Net Cash Provided by (Used in) Operating Activities [Abstract]
Fair Value, Recurring [Member]
Fair Value, Measurements, Recurring
Restructuring and Related Activities [Abstract]
Vesting [Axis]
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Net unrealized loss on marketable securities
Statement of Cash Flows [Abstract]
Antidilutive Securities, Name
Antidilutive Securities, Name [Domain]
Issuance of common stock upon vesting of restricted stock units
Stock issued during period shares vesting of restricted stock units.
Stock Issued During Period Shares Vesting Of Restricted Stock Units
Exercisable warrants remaining
Class Of Warrant Or Right, Number Of Securities Exercisable Class Of Warrant Or Right, Remaining Number Of Securities Exercisable
Class of warrant or right, number of securities exercisable class of warrant or right, remaining number of securities exercisable.
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Warrants issued to purchase shares of common stock
Other noncurrent liabilities
Increase (Decrease) in Other Noncurrent Liabilities
Pre funded warrant.
Pre Funded Warrant [Member]
Pre Funded Warrant
Restricted Stock
Restricted Stock [Member]
Restricted Stock Subject to Future Vesting
Stock issued during period value issuance of warrant.
Stock Issued During Period Value Issuance Of Warrant
Issuance of warrant
Balance Sheet Related Disclosures [Abstract]
Equity Components
Equity Components [Axis]
Entity Address, Address Line One
Entity Address, Address Line One
Granted
Stock option awards granted period
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Computer Equipment [Member]
Computer Equipment and Software
Property Plant And Equipment [Line Items]
Property, Plant and Equipment [Line Items]
Stock Option, Exercise Price, Decrease
Reduction in exercise price of eligible stock option awards
Subsequent Event Type [Axis]
Total other income, net
Nonoperating Income (Expense)
Lease initial expiration month and year
Lease initial expiration month and year.
Schedule of Antidilutive Securities Excluded from Computation of Diluted Net Loss Per Share
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Principal Amount
Line of Credit Facility, Maximum Borrowing Capacity
Risk-free interest rate
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Unvested as of December 31, 2024
Unvested as of Martch 31, 2025
Commitments And Contingencies [Table]
Commitments And Contingencies [Table]
Commitments and contingencies.
Amendment Flag
Amendment Flag
Operating lease liabilities
Increase (Decrease) in Operating Lease Liability
Schedule of Prepaid Expenses and Other Current Assets.
Schedule of Prepaid Expenses and Other Current Assets [Table Text Block]
Summary of Prepaid Expenses and Other Current Assets
Operating lease liabilities, noncurrent
Operating Lease, Liability, Noncurrent
Debt Instrument, Name [Domain]
Union City, California
Union City California [Member]
Union City, California.
Restructuring Plan [Domain]
Sale of Stock, Price Per Share
Common stock, per share
Net loss
Net loss
Issuance of common stock upon exercise of stock options, shares
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Exercised
Share-Based Compensation Arrangement by Share-Based Payment Award, Shares Issued in Period
Number of shares issued under the Inducement plan
Research and Development Expense [Member]
Research
Research and development
Shares available for further issuance under inducement plan.
Shares Available for Further Issuance under Inducement Plan [Member]
Shares Available for Further Issuance under the 2024 Inducement Equity Incentive Plan
Manufacturing Equipment
Manufacturing Facility [Member]
Commence Date
Debt Instrument, Maturity Date Range, Start
Equity Component
Equity Component [Domain]
Statistical Measurement
Statistical Measurement [Domain]
General and Administrative Expense, Total
General and administrative
General and Administrative Expense
Accrued research and development expenses
Accrued Research And Development Expenses
Accrued research and development expenses.
Balance Sheet Components
Supplemental Balance Sheet Disclosures [Text Block]
Other Nonoperating Income (Expense), Total
Other Nonoperating Income (Expense)
Other income, net
Common stock shares available for issuance period
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period
Outstanding pre-funded warrants.
Outstanding Pre-Funded Warrants [Member]
Outstanding Pre-Funded Warrants
Furniture and Fixtures
Furniture and Fixtures [Member]
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Net loss
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Operating Lease, Payments
Cash paid for amounts included in the measurement of lease liabilities
US Government Corporations and Agencies Securities [Member]
Government Agencies Bonds
Outstanding lender warrant.
Outstanding Lender Warrant [Member]
Outstanding Lender Warrant
Issuance of common stock pursuant to employee stock purchase plan, shares
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Short-Term Investments, Total
Short-Term Investments
Short-term investments in marketable securities
Prepaid expenses and other current assets
Prepaid Expense and Other Assets, Current
Total prepaid expenses and other current assets
Risk free interest rate, maximum
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Maximum
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Cancelled
Prepaid expenses and other current assets
Increase Decrease In Prepaid Expense And Other Current Assets
Increase (decrease) in prepaid expense and other current assets.
Prepaid expenses and other current assets
Restricted cash included in other noncurrent assets
Restricted Cash, Noncurrent
Other Comprehensive Income (Loss), Net of Tax, Total
Other Comprehensive Income (Loss), Net of Tax
Other comprehensive income (loss)
Reconciliation of Operating Profit (Loss) from Segments to Consolidated [Table]
Comprehensive loss
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Union city facility.
Union City Facility [Member]
Union City Facility
Increase Decrease In Accrued Liabilities And Other Current Liabilities
Increase (decrease) in accrued liabilities and other current liabilities.
Accrued and other current liabilities
Current loan amount available
Line of Credit Facility, Current Borrowing Capacity
Issuance Of Common Stock And Warrants Value Net Of Issuance Costs
Issuance of common stock and warrants value net of issuance costs.
Issuance of common stock and warrants, net of issuance costs
Antidilutive Securities
Antidilutive Securities [Axis]
Number of lease renewal term
Number Of Lease Renewal Term
Number of lessee lease renewal term.
Proceeds from Issuance or Sale of Equity, Total
Proceeds from Issuance or Sale of Equity
Proceeds from issuance of equity, net of issuance costs
Summary of Restricted Stock Activity
Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block]
Follow-On Offering.
Follow-On Offering [Member]
Follow On Offering
Follow-on Offering
Entity Interactive Data Current
Entity Interactive Data Current
Minimum Bid Price of Common Stock
Minimum bid price of common stock.
Minimum id price of common stock
Lease Expiration Date
Lease Expiration Date
Document Quarterly Report
Document Quarterly Report
Vested
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Ending Balance
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Beginning Balance
Cash, cash equivalents and restricted cash
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents
Statistical Measurement
Statistical Measurement [Axis]
Operating Lease, Cost
Operating lease cost
Clinical
Clinical [Member]
Clinical.
Series A Warrant [Member]
Series a warrant.
Series A Warrant
Commercial Paper, Not Included with Cash and Cash Equivalents [Member]
Commercial Paper
Lease, Cost
Total lease cost
Summary of Future Minimum Lease Payments Under Operating Lease
Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block]
Debt Instrument, Redemption, Period Three [Member]
Third Tranche
Commercial Paper [Member]
Commercial Paper
Shares reserved and available for grant
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Offering period
Weighted-average period
Income Statement Location
Statement of Income Location, Balance [Axis]
Cash and Cash Equivalents [Axis]
Total assets
Assets
Expected term (in years)
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Vested
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
New Accounting Pronouncements, Policy [Policy Text Block]
Recently Issued Accounting Pronouncements Note Yet Adopted
Entity Address, City or Town
Entity Address, City or Town
Accumulated Other Comprehensive Loss
AOCI Attributable to Parent [Member]
Equity [Abstract]
Stock issuance costs
Payments of Stock Issuance Costs
Payment of accrued offering costs
Forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items]
Restructuring Cost and Reserve [Line Items]
Lender warrant.
Lender Warrant [Member]
Lender Warrant
Stock-Based Compensation
Share-Based Payment Arrangement [Text Block]
Construction in Progress
Construction in Progress [Member]
Weighted-average discount rate
Operating Lease, Weighted Average Discount Rate, Percent
Segment Reporting, CODM, Individual Title and Position or Group Name [Extensible Enumeration]
Fair Value Disclosures [Abstract]
Issuance of common stock and warrants, net of issuance costs, shares
Issuance Of Common Stock And Warrants Net of Issuance Costs Shares
Issuance of common stock and warrants net of issuance costs shares.
Issuance of common stock in connection with at-the-market sales, net of issuance costs
Stock Issued During Period, Value, New Issues
Issuance of common stock in connection with at-the-market sales, net of issuance costs
Chief Executive Officer
Chief Executive Officer [Member]
California Institute for Regenerative Medicine Grant [Policy Text Block]
California institute for regenerative medicine grant.
CIRM Grant
Issuance of common stock upon exercise of stock options
Stock Issued During Period, Value, Stock Options Exercised
Current liabilities:
Liabilities, Current [Abstract]
Accrued facility management service fee.
Accrued Facility Management Service Fee
Accrued facility management services
Cash and Cash Equivalents [Member]
Document Type
Document Type
Government Agencies Bonds
US Government Agencies Debt Securities [Member]
Payments for (Proceeds from) Other Investing Activities
Other
Title of 12(b) Security
Title of 12(b) Security
Cash and Cash Equivalents, at Carrying Value, Ending Balance
Cash and Cash Equivalents, at Carrying Value, Beginning Balance
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value
Amortized Cost
Amortized Cost
Participants to purchase shares through payroll deduction at lower percentage of fair market value
Share-Based Compensation Arrangement by Share-Based Payment Award, Discount from Market Price, Purchase Date
Lease, Cost [Table Text Block]
Summary of Operating Lease Activity
Debt Instrument, Redemption, Period [Axis]
Statement of Stockholders' Equity [Abstract]
Document Fiscal Period Focus
Document Fiscal Period Focus
Research and Development Expense, Total
Research and development expense related to upfront license fee payable
Research and development
Research and Development Expense
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Granted
Asset Class [Domain]
Property, Plant and Equipment, Gross, Ending Balance
Property, Plant and Equipment, Gross, Beginning Balance
Property, Plant and Equipment, Gross, Total
Total property and equipment
Property, Plant and Equipment, Gross
Debt Instrument, Redemption, Period Two [Member]
Second Tranche
Subsequent Event Type [Domain]
Summary of Fair Value of Stock Option Awards
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
2021 Equity Incentive Plan
Two Thousand And Twenty One Equity Incentive Plan [Member]
Two thousand and twenty one equity incentive plan.
Accrued Property Taxes
Accrued property taxes .
Accrued taxes
Class of Warrant or Right, Exercise Price of Warrants or Rights
Warrants, exercise price
Financial Instruments [Domain]
Number of option remaining to extend the lease term
Number Of Option Remaining To Extend The Lease Term
Number of option remaining to extend the lease term.
Sale of Stock
Sale of Stock [Axis]
Cash flows from investing activities:
Net Cash Provided by (Used in) Investing Activities [Abstract]
Shares available for further issuance under the 2021 Employee Stock Purchase Plan member
Shares available for further issuance under the 2021 Employee Stock Purchase Plan member
Shares Available for Further Issuance under the 2021 Employee Stock Purchase Plan
Income Taxes
Income Tax Disclosure [Text Block]
Line of Credit Facility [Line Items]
Lease expiration month and year
Lease Expiration Month And Year
Lease Expiration month and year.
Credit Facility [Domain]
Depreciation, Depletion and Amortization, Nonproduction, Total
Depreciation and amortization expense
Depreciation, Depletion and Amortization, Nonproduction
Significant Accounting Policies [Table]
Significant accounting policies.
Significant Accounting Policies [Table]
Increase (Decrease) in Accounts Payable, Total
Accounts payable
Increase (Decrease) in Accounts Payable
Entity Address, Address Line Two
Entity Address, Address Line Two
LIABILITIES, CONVERTIBLE PREFERRED STOCK AND STOCKHOLDERS’ EQUITY (DEFICIT)
Liabilities and Equity [Abstract]
Document Period End Date
Document Period End Date
Net cash provided by financing activities
Net Cash Provided by (Used in) Financing Activities
Other offering expenses.
Other Offering Expenses
Other offering expenses
Incremental Stock-based compensation expense
Employee Benefits and Share-Based Compensation
Potentially dilutive securities were not included in the calculation of diluted net loss per share
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
APIC, Share-based Payment Arrangement, Increase for Cost Recognition, Total
Stock-based compensation
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Accrued Liabilities, Current
Total accrued and other current liabilities
Accrued and other current liabilities
At the market sales agreement.
At The Market Sales Agreement [Member]
At-the-Market Equity Offering
Segment Reporting, CODM, Profit (Loss) Measure, How Used, Description
Income Tax Expense (Benefit), Total
Income tax expense
Income Tax Expense (Benefit)
Commissions and Offering Costs
Commissions and offering costs.
Commissions and offering costs
Trading Symbol
Trading Symbol
Total stockholders' equity
Balance
Balance
Equity, Attributable to Parent
Number of Shares
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Participants to purchase common stock through payroll deduction annual limit of eligible compensation
Participants To Purchase Common Stock Through Payroll Deduction Annual Limit Of Eligible Compensation
Participants to purchase common stock through payroll deduction annual limit of eligible compensation.
Outstanding Series A And B Warrants [Member]
Outstanding series A and B warrants.
Outstanding Series A and B Warrants
Long-Lived Tangible Asset
Long-Lived Tangible Asset [Axis]
Other noncurrent liabilities
Other Liabilities, Noncurrent, Total
Other Liabilities, Noncurrent
Sale of Stock, Number of Shares Issued in Transaction
Number of common shares
Variable lease payments
Variable Lease, Cost
Variable lease cost
Schedule Of Property Plant And Equipment [Table]
Property, Plant and Equipment [Table]
Summary of Stock-based Compensation
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Geographical
Geographical [Axis]
Unrealized Loss
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax
Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Remaining incremental stock-based compensation expense
Laboratory Equipment
Equipment [Member]
Use of Estimates
Use of Estimates, Policy [Policy Text Block]
Issurance of common stock and pre - funded warrants value net of issuance costs.
Issurance Of Common Stock And Pre - Funded Warrants Value Net Of Issuance Costs
Issuance of common stock and pre-funded warrants, net of issuance costs
Stock Issued During Period, Value, Conversion of Convertible Securities
Issuance of common stock upon exercise of pre-funded warrants
Number of shares of common stock that may be issued in accordance with the plan
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares That May Be Issued In Accordance With Plan
Share based compensation arrangement by share based payment award number of shares that may be issued in accordance with the plan.
Class Of Stock [Line Items]
Class of Stock [Line Items]
Expected volatility, minimum
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Minimum
Expected dividend yield
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Security Exchange Name
Security Exchange Name
Significant accounting policies.
Significant Accounting Policies [Line Items]
Significant Accounting Policies [Line Items]
Total operating expenses
Operating Expenses
Long-Lived Tangible Asset
Long-Lived Tangible Asset [Domain]
Number of share exercisable
Class Of Warrant Or Right, Number Of Securities ExercisableClass Of Warrant Or Right, Number Of Securities Exercisable
Class of warrant or right, number of securities exercisable.
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Less: accumulated depreciation and amortization
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Fair Value Measurements
Fair Value Disclosures [Text Block]
Lessee, Operating Lease, Liability, to be Paid, Year Three
2028
Percentage of shares of common stock outstanding on last day of immediately preceding year
Percentage Of Shares Of Common Stock Outstanding On Last Day Of Immediately Preceding Year
Percentage of shares of common stock outstanding on last day of immediately preceding year.
Subsequent Event
Subsequent Event [Member]
Maximum
Maximum [Member]
Restructuring and Related Activities Disclosure [Text Block]
Workforce Reduction
Total liabilities and stockholders' equity
Liabilities and Equity
Office and Laboratory Space
Office And Laboratory Space [Member]
Office and laboratory space.
Operating lease right-of-use assets
Operating Lease, Right-of-Use Asset
Prepaid Expense, Current, Total
Prepaid Expense, Current
Prepaid expenses
Net loss per share, diluted
Earnings Per Share, Diluted
Earnings Per Share, Diluted, Total
Leasehold Improvements
Leasehold Improvements [Member]
Entity Ex Transition Period
Entity Ex Transition Period
Total liabilities
Liabilities
Share Based Compensation Arrangement By Share Based Payment Award Options Exercise Price Per Share
Share based compensation arrangement by share based payment award options exercise price per share.
Per share exercise price of eligible stock option awards
Restructuring and Related Cost, Expected Cost, Total
Restructuring and Related Cost, Expected Cost
Estimates aggregate charges
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Domain]
Assets, Current
Total current assets
Net Cash Provided by (Used in) Investing Activities
Net cash provided by investing activities
Stock Issued During Period, Shares, New Issues
Issuance of common stock in connection with at-the market sales, net of issuance costs , Shares
Issuance of common stock in connection with at-the market sales, net of issuance costs , Shares
Vesting period
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Lessee, Operating Lease, Existence of Option to Extend [true false]
Entity Filer Category
Entity Filer Category
Schedule of Common Stock Reserved for Issuance
Schedule Of Common Stock Reserved For Issuance Table [Text Block]
Schedule of common stock reserved for issuance.
Debt Instrument, Redemption, Period [Domain]
Stock issued during period value stock options exercised and vesting of restricted stock units.
Stock Issued During Period Value Stock Options Exercised And Vesting Of Restricted Stock Units
Issuance of common stock upon exercise of stock options and vesting of restricted stock units
Organization and Description of the Business
Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]
Payments to Acquire Marketable Securities, Total
Purchases of marketable securities
Payments to Acquire Marketable Securities
Other income, net:
Nonoperating Income (Expense) [Abstract]
Second Amendment
Second Amendment Member.
Current Fiscal Year End Date
Current Fiscal Year End Date
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Imputed interest
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Share-based Payment Arrangement, Noncash Expense, Total
Stock-based compensation
Share-Based Payment Arrangement, Noncash Expense
Entity Registrant Name
Entity Registrant Name
Number of Reportable Segments
Number of reportable segment
Number of renewal options
Number of Renewal Options
Number of renewal options.
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Net Loss Per Share
Earnings Per Share [Text Block]
Entity Emerging Growth Company
Entity Emerging Growth Company
Money Market Funds [Member]
Money Market Funds
Other Liabilities, Current, Total
Other Liabilities, Current
Other liabilities, current
Other current liabilities
Weighted-average shares used in computing net loss per share, basic
Weighted Average Number of Shares Outstanding, Basic
Weighted Average Number of Shares Outstanding, Basic, Total
Vesting [Domain]
Expected volatility, maximum
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Maximum
Proceeds from at-the-market sales, net of issuance costs
Proceeds from issuance of common stock at the market
Proceeds from exercises of pre-funded warrants
Proceeds from Sale and Maturity of Marketable Securities, Total
Proceeds from maturities of marketable securities
Proceeds from Sale and Maturity of Marketable Securities
Level 1
Fair Value, Inputs, Level 1 [Member]
Class of warrant or right exercise price of warrants or rights1 price per share.
Class Of Warrant Or Right Exercise Price Of Warrants Or Rights1 Price Per Share
Class of warrant price per share
Additional warrants exercisable
Class Of Warrant Or Right Number Of Securities Exercisable Class Of Warrant Or Right Additional Number Of Securities Exercisable
Class of warrant or right number of securities exercisable class of warrant or right additional number of securities exercisable.
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Granted
Financial Instrument [Axis]
Contractual term of stock option awards
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Outstanding stock options and restricted stock units.
Outstanding Stock Options And Restricted Stock Units [Member]
Outstanding Stock Options and Restricted Stock Units
General and Administrative Expense [Member]
General and Administrative
Share-Based Payment Arrangement [Abstract]
Debt Securities [Member]
Marketable Securities
Restructuring Plan [Axis]
Available-for-sale marketable securities
Debt Securities, Available-for-sale, Total
Fair Value
Debt Securities, Available-for-Sale
Accounting Policies [Abstract]
US treasury securities, not Included with cash and cash equivalents.
US Treasury Securities Not Included With Cash And Cash Equivalents [Member]
U.S. Treasuries
Summary of Stock Option Activity
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Twenty twenty four inducement equity incentive plan.
Twenty Twenty Four Inducement Equity Incentive Plan [Member]
2024 Inducement Equity Incentive Plan
Income Tax Disclosure [Abstract]
Stockholders' equity:
Equity, Attributable to Parent [Abstract]
Supplemental disclosure of non-cash investing and financing activities:
Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]
Statement [Table]
Statement [Table]
Offering expenses.
Offering Expenses
Offering expenses
Summary of Property and Equipment, Net
Property, Plant and Equipment [Table Text Block]
Maximum aggregate offering price
Maximum Aggregate Offering Price
Maximum aggregate offering price.
Subsequent Event [Table]
Compliance Period
Compliance period.
Compliance period
Warrant exercisable percentage
Class of Warrant or Right Number Of Securities Exercisable Percentage
Class of warrant or right number of securities exercisable percentage.
Entity File Number
Securities Act File Number
Segment Reporting
Segment Reporting Disclosure [Text Block]
Net change in cash, cash equivalents and restricted cash
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Earnings Per Share [Abstract]
Maximum borrowing capacity of term loans.
Maximum Borrowing Capacity of Term Loans
Maximum borrowing capacity of term loans
Cash Equivalents [Member]
Cash Equivalents
Warrants and Rights Outstanding, Term
Warrant expiration term
Statement of Financial Position [Abstract]
Loss from operations
Operating Income (Loss)
Shares Issued, Price Per Share
Public offering price per unit
Expected volatility
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Entity Shell Company
Entity Shell Company
Line of Credit Facility [Table]
Accrued professional services
Accrued Professional Fees, Current
Entity Tax Identification Number
Entity Tax Identification Number
ASSETS
Assets [Abstract]
Class of Warrant or Right [Domain]
Debt Instrument, Redemption, Period Four [Member]
Fourth Tranche
Entity Current Reporting Status
Entity Current Reporting Status
Summary of Fair Value of Financial Assets Measured at Fair Value on Recurring Basis
Fair Value, Liabilities Measured on Recurring Basis [Table Text Block]
Schedule of Accounts Payable and Accrued Liabilities [Table Text Block]
Summary of Accrued and Other Current Liabilities
Subsequent Events [Abstract]
Geographical
Geographical [Domain]
Document Fiscal Year Focus
Document Fiscal Year Focus
Cash, Cash Equivalents, and Short-term Investments, Total
Cash, cash equivalents and investments in marketable securities
Cash, Cash Equivalents, and Short-Term Investments
Stock Issued During Period Shares Stock Options Vesting Of Restricted Stock Units
Stock issued during period shares stock options vesting of restricted stock units.
Issuance of common stock upon vesting of restricted stock units, shares
Accrued compensation and related expenses
Accrued Compensation And Related Expenses
Accrued compensation and related expenses.
Share-Based Payment Arrangement, Tranche Two [Member]
Share-Based Payment Arrangement, Tranche Two
Capital Expenditures Incurred but Not yet Paid
Property and equipment included in accounts payable and accrued and other current liabilities
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total
Cash and cash equivalents and restricted cash at beginning of period
Cash and cash equivalents and restricted cash at end of period
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations
Shares available for further issuance under the 2021 Equity Incentive Plan member
Shares available for further issuance under the 2021 Equity Incentive Plan member
Shares Available for Further Issuance under the 2021 Equity Incentive Plan
City Area Code
City Area Code
Total current liabilities
Liabilities, Current
Number of Common Shares in Each Unit
Number of common shares in each unit.
Number of common shares in each unit
Lease expiration month and year, start
Lease Expiration Month And Year start
Lease expiration month and year start.
Stock Issued During Period, Shares, Conversion of Convertible Securities
Issuance of common stock upon exercise of pre-funded warrants, shares
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Local Phone Number
Local Phone Number
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Additional Paid in Capital, Ending Balance
Additional Paid in Capital, Beginning Balance
Additional Paid in Capital, Total
Additional paid-in capital
Additional Paid in Capital
Participants to purchase common stock through payroll deduction maximum percentage of eligible compensation
Participants To Purchase Common Stock Through Payroll Deduction Maximum Percentage Of Eligible Compensation
Participants to purchase common stock through payroll deduction maximum percentage of eligible compensation.
Commitments and Contingencies Disclosure [Abstract]
Amortized Cost
Debt Securities, Available-for-Sale, Amortized Cost
Consecutive business days
Consecutive Business Days
Consecutive business days.
Amortization (accretion) of premium (discount) on marketable securities
Amortization Of Premium On Marketable Securities
Amortization Of Premium On Marketable Securities
Operating lease liabilities, current
Operating Lease, Liability, Current
Accumulated Deficit
Retained Earnings [Member]
Payments to Acquire Property, Plant, and Equipment, Total
Purchases of property and equipment
Payments to Acquire Property, Plant, and Equipment
Document Transition Report
Document Transition Report
Lessee, Operating Lease, Liability, to be Paid, Year Two
2027
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Antidilutive Security, Excluded EPS Calculation [Table]
Exercised
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Other
Other [Member]
Other.
Components of cash, cash equivalents and restricted cash:
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations [Abstract]
Minimum
Minimum [Member]
Minimum [Member]
Outstanding Stock Options and Awards
Outstanding Stock Options and Awards [Member]
Outstanding stock options and awards
Common Stock
Common Stock [Member]
Series B Warrant [Member]
Series b warrant.
Series B Warrant
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Unvested as of December 31, 2024
Unvested as of March 31, 2025
Other noncurrent assets
Increase (Decrease) in Other Noncurrent Assets
Non-cash operating lease expense
Operating Lease, Right-of-Use Asset, Periodic Reduction
Additional Paid-In Capital
Additional Paid-in Capital [Member]
Grant Awarded Upon Achievement Of Milestones Based On Clinical Trials
Grant awarded upon achievement of milestones based on clinical trials.
Grant awarded upon achievement of milestones
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Issuance of warrant in connect with Loan Agreement.
Issuance of Warrant in Connect With Loan Agreement
Issuance of warrant in connection with Loan Agreement
Income Statement Location
Statement of Income Location, Balance [Domain]
Lessee, Operating Lease, Liability, to be Paid, Year One
2026
Other noncurrent assets
Other Assets, Noncurrent, Total
Other Assets, Noncurrent
Proceeds from Sale of Debt Securities, Available-for-Sale
Proceeds from sales of marketable securities
Other Assets, Current
Other current assets
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Basis of Presentation
Basis of Accounting, Policy [Policy Text Block]
Lease commenced month and year
Lessee Operating Lease Commenced
Lessee operating lease commenced.
Title and Position [Domain]
Common Stock, Value, Issued, Ending Balance
Common Stock, Value, Issued, Beginning Balance
Common Stock, Value, Issued, Total
Common stock
Common Stock, Value, Issued
Interest income
Investment Income, Interest
Thereafter
Lessee Operating Lease Liability Payments Due After Year Four
Lessee operating lease liability payments due after year four.
Incremental Stock-based compensation expense
Share-Based Payment Arrangement, Accelerated Cost
Total operating lease liabilities
Operating Lease, Liability, Total
Operating lease liabilities
Operating Lease, Liability
Proceeds from exercise of stock options and employee stock purchase plan
Proceeds from Exercise of Stock Options and Employee Stock Purchase Plan
Proceeds from exercise of stock options and employee stock purchase plan
Measurement Frequency [Axis]
Commitments and Contingencies
Commitments and contingencies (Note 4)
Weighted-average shares used in computing net loss per share, diluted
Weighted Average Number of Shares Outstanding, Diluted
Weighted Average Number of Shares Outstanding, Diluted, Total
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Employee Benefits And Share Based Compensation Vested Repriced Options
Employee benefits and share based compensation vested repriced options.
Incremental Stock-based compensation expense vested repriced options
Schedule of Segment Reporting Information, by Segment [Table Text Block]
Schedule of Operating Expenses by Function
Lease renewal term
Lessee, Operating Lease, Renewal Term
Total undiscounted future minimum lease payments
Lessee, Operating Lease, Liability, to be Paid
Inducement plan.
Inducement Plan [Member]
Inducement Plan
Lessee, option to extend term
Lessee, Operating Lease, Option To Extend Term
Lessee, operating lease, option to extend term.
Issuance of common stock and pre-funded warrants, net of issuance costs, shares.
Issuance Of Common Stock And Pre-funded Warrants, Net Of Issuance Costs, Shares
Issuance of common stock and pre-funded warrants, net of issuance costs, shares
Warrants expires date
Warrants and Rights Outstanding, Maturity Date
Entity Small Business
Entity Small Business
Debt Disclosure [Text Block]
U.S. Treasuries
US Treasury Securities [Member]
Line of Credit Facility [Abstract]
Credit Facility [Axis]
Stock Options Repricing Impact In Stock Option Award
Stock options repricing impact in stock option award.
Stock option repricing impact in stock option awards
Cash flows from financing activities:
Net Cash Provided by (Used in) Financing Activities [Abstract]
Weighted-Average Exercise Price Per Share, Outstanding Beginning Balance
Weighted-Average Exercise Price Per Share, Outstanding Ending Balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Stock options exercise price per share
Asset Class [Axis]
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Operating lease right-of-use assets obtained in exchange for lease obligations
Measurement Frequency [Domain]
Weighted-average remaining lease term
Operating Lease, Weighted Average Remaining Lease Term
Subsequent Events [Text Block]
Subsequent Event
Accounts Payable, Current, Total
Accounts payable
Accounts Payable, Current
Weighted Average Grant Date Fair Value per Share
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Short-term lease
Short-Term Lease, Cost
Short-term lease cost