75000 - Document - Document and Entity Information
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75010 - Statement - Balance Sheets
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75020 - Statement - Balance Sheets (Parenthetical)
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75030 - Statement - Statements of Operations and Comprehensive Loss
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75040 - Statement - Statements of Stockholders' Equity
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75050 - Statement - Statements of Stockholders' Equity (Parenthetical)
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75060 - Statement - Statements of Cash Flows
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995455 - Disclosure - Cybersecurity Risk Management, Strategy and Governance
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995465 - Disclosure - Organization and Description of the Business
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995475 - Disclosure - Summary of Significant Accounting Policies
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995485 - Disclosure - Balance Sheet Components
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995495 - Disclosure - License Agreements
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995505 - Disclosure - Commitments and Contingencies
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995515 - Disclosure - Term Loan
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995525 - Disclosure - Convertible Preferred Stock
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995535 - Disclosure - Stockholders' Equity
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995545 - Disclosure - Fair Value Measurements
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995555 - Disclosure - Stock-Based Compensation
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995565 - Disclosure - Income Taxes
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995575 - Disclosure - Net Loss Per Share
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995585 - Disclosure - Related Party Transactions
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995595 - Disclosure - Workforce Reduction
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995605 - Disclosure - Segment Reporting
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995615 - Disclosure - Subsequent Events
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995625 - Disclosure - Summary of Significant Accounting Policies (Policies)
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995635 - Disclosure - Balance Sheet Components (Tables)
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995645 - Disclosure - Commitment and Contingencies (Tables)
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995655 - Disclosure - Stockholders' Equity (Tables)
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995665 - Disclosure - Fair Value Measurements (Tables)
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995675 - Disclosure - Stock-Based Compensation (Tables)
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995685 - Disclosure - Income Taxes (Tables)
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995695 - Disclosure - Net Loss Per Share (Tables)
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995705 - Disclosure - Segment Reporting (Tables)
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995715 - Disclosure - Organization and Description of the Business - Additional Information (Details)
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995725 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Details)
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995735 - Disclosure - Balance Sheet Components - Summary of Property and Equipment, Net (Details)
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995745 - Disclosure - Balance Sheet Components - Additional Information (Details)
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995755 - Disclosure - Balance Sheet Components - Summary of Accrued Expenses and Other Current Liabilities (Details)
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995765 - Disclosure - Balance Sheet Components - Summary of Prepaid Expenses and Other Current Assets (Details)
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995775 - Disclosure - License Agreements (Details)
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995785 - Disclosure - Commitments and Contingencies - Additional Information (Details)
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995795 - Disclosure - Commitments and Contingencies - Summary of Operating Lease Activity (Details)
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995805 - Disclosure - Commitments and Contingencies - Summary of Future Minimum Lease Payments Under Operating Leases (Details)
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995815 - Disclosure - Commitments and Contingencies - Summary of Future Minimum Lease Payments Under Operating Leases (Details) 2
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995825 - Disclosure - Term Loan - Additional Information (Details)
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995835 - Disclosure - Convertible Preferred Stock - Additional Information (Details)
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995845 - Disclosure - Stockholders' Equity - Additional Information (Details)
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995855 - Disclosure - Stockholders' Equity - Schedule of Common Stock Reserved for Issuance (Details)
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995865 - Disclosure - Fair Value Measurements - Summary of Fair Value of Financial Assets Measured at Fair Value on Recurring Basis (Details)
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995875 - Disclosure - Fair Value Measurements - Summary of Amortized Cost and Fair Value of Available for Sale Debt Securities (Details)
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995885 - Disclosure - Fair Value Measurements - Additional Information (Details)
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995895 - Disclosure - Fair Value Measurements - Summary of Changes in Estimated Fair Value Liabilities Measures at Fair Value on a Recurring Basis (Details)
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995905 - Disclosure - Fair Value Measurements - Summary of Significant Unobservable Assumptions used to Convertible Preferred Stock Tranche Liability (Details)
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995915 - Disclosure - Stock-Based Compensation - Additional Information (Details)
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995925 - Disclosure - Stock-Based Compensation - Summary of Stock Option Activity (Details)
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995935 - Disclosure - Stock-Based Compensation - Summary of Fair Value of Stock Option Awards (Details)
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995945 - Disclosure - Stock-Based Compensation - Summary of Restricted Stock Activity (Details)
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995955 - Disclosure - Stock-Based Compensation - Summary of Stock-based Compensation (Details)
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995965 - Disclosure - Income Taxes - Additional information (Details)
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995975 - Disclosure - Income Taxes - Schedule of Effective Tax Rate Reconciliation (Details)
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995985 - Disclosure - Income Taxes - Schedule of Effective Tax Rate Reconciliation (Details) 2
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995995 - Disclosure - Income Taxes - Schedule of Deferred Income Taxes (Details)
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996005 - Disclosure - Income Taxes - Summary of Net Operating Loss and Tax Carryforwards (Details)
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996015 - Disclosure - Income Taxes - Schedule of Unrecognized Tax Benefits (Details)
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996025 - Disclosure - Net Loss Per Share - Schedule of Antidilutive Securities Excluded from Computation of Diluted Net Loss Per Share (Details)
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996035 - Disclosure - Workforce Reduction - Additional Information (Details)
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996045 - Disclosure - Segment Reporting - Additional Information (Details)
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996055 - Disclosure - Segment Reporting - Schedule of Operating Expenses by Function (Details)
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996065 - Disclosure - Subsequent Events - Additional Information (Details)
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Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Vested
Eligible to Receive Development, Regulatory and Sales-based Milestones
Eligible to receive development, regulatory and sales-based milestones.
Eligible to receive development, regulatory and sales-based milestones
Effective Income Tax Rate Reconciliation, Tax Credit, Orphan drug credit, Amount
Effective income tax rate reconciliation, tax credit, orphan drug credit.
Orphan drug credit
Orphan drug credit
Commitments and contingencies.
Commitments And Contingencies [Line Items]
Commitments And Contingencies [Line Items]
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Preferred Stock, Shares Issued, Total
Preferred Stock, Shares Issued
Preferred stock, issued
Statement of Financial Position Location, Balance [Domain]
Balance Sheet Location
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value
Ending balance
Beginning balance
Tax credits:
Effective Income Tax Rate Reconciliation, Tax Credit, Amount [Abstract]
Increase (Decrease) in Accounts Payable, Total
Increase (Decrease) in Accounts Payable
Accounts payable
Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]
Supplemental disclosure of non-cash investing and financing activities:
Operating Leases, Future Minimum Payments, Remainder of Fiscal Year
2021
Debt Securities, Available-for-Sale, Fair Value, Maturity, Allocated and Single Maturity Date, Year One
Available-for-sale marketable securities remaining maturities less than one year
Impairment charges on marketable securities related to other-than-temporary
Impairment Charges On Marketable Securities Related To Other Than Temporary
Impairment charges on marketable securities related to other-than-temporary.
Plan Name [Axis]
Plan Name
Equity [Abstract]
Entity Current Reporting Status
Entity Current Reporting Status
Manufacturing [Member]
Manufacturing.
Manufacturing (pre-commercial)
Proceeds from Warrant Exercises
Proceeds from exercise of warrants
US Government Agencies Debt Securities [Member]
Government Agencies Bonds
Operating Expenses [Abstract]
Operating expenses:
Additional amount available upon satisfaction of certain milestones
Line Of Credit Facility, Capacity Available For Satisfaction Of Certain Milestones
Line of credit facility, capacity available for satisfaction of certain milestones.
Fair Value, Inputs, Level 2 [Member]
Level 2
Deferred tax assets, net of valuation allowance
Deferred Tax Assets, Net of Valuation Allowance
Deferred tax assets, net of valuation allowance
Commitments and Contingencies Disclosure [Text Block]
Commitments and Contingencies
Convertible Preferred Stock
Convertible preferred stock.
Convertible Preferred Stock [Text Block]
Percentage of Reduction in Workforce
Percentage of reduction in workforce.
Percentage of reduction in workforce
Common Stock, Shares Authorized
Common stock, authorized
Feb 2024 Follow-On Offering
At The Market Sales
At The Market Offering Member
At the market offering member.
Other Nonoperating Income (Expense) [Member]
Other Income (Expense), Net
Temporary Equity, Par or Stated Value Per Share
Temporary equity, par value
Asset Retirement Obligation [Policy Text Block]
Asset Retirement Obligation
Fair Value by Liability Class [Domain]
Fair Value by Liability Class
Aggregate charges, incurred
Restructuring and Related Cost, Cost Incurred to Date
Document Fiscal Period Focus
Issuance of common stock upon exercise of stock options and vesting of restricted stock units, shares
Stock Issued During Period Shares Stock Options Exercised And Vesting of Restricted Stock Units
Stock issued during period shares stock options exercised and vesting of restricted stock units.
Entity Shell Company
Entity Shell Company
Shares Outstanding
Temporary Equity, Shares Outstanding
Temporary equity balance, shares
Temporary equity balance, shares
Temporary equity, outstanding
Available-for-sale marketable securities contractual maturities term
Available For Sale Marketable Securities Contractual Maturities Term
Available-for-sale marketable securities contractual maturities term.
Manufacturing and office space.
Manufacturing And Office Space [Member]
Manufacturing and Office Space
Early exercised stock options and restricted stock that are unvested and subject to repurchase.
Early Exercised Stock Options And Restricted Stock That Are Unvested And Subject To Repurchase [Member]
Early Exercised Stock Options and Restricted Stock That are Unvested and Subject to Repurchase
South San Francisco, California.
South San Francisco California [Member]
South San Francisco, California
Maximum additional shares issuable
Maximum Additional Shares Isssuable Value
Maximum Additional Shares Isssuable Value
Segment Information
Segment Reporting, Policy [Policy Text Block]
Cash and Cash Equivalents, at Carrying Value, Ending Balance
Cash and Cash Equivalents, at Carrying Value, Beginning Balance
Cash and Cash Equivalents, at Carrying Value, Total
Cash and Cash Equivalent
Cash and cash equivalents
Lease liability
Deferred Tax Assets ,Lease Liability
Deferred tax assets ,lease liability.
Series B convertible preferred stock.
Series B Convertible Preferred Stock [Member]
Series B Convertible Preferred Stock
Outstanding Series A and Series B Warrants [Member]
Outstanding Series A and Series B warrants.
Outstanding Series A and Series B Warrants
Cybersecurity Risk Management, Strategy, and Governance [Abstract]
Common Stock, Shares, Issued, Total
Common Stock, Shares, Issued
Common stock, issued
Cybersecurity Risk Management Positions or Committees Responsible Report to Board [Flag]
Cybersecurity Risk Board of Directors Oversight [Text Block]
Asset Class [Domain]
Statement [Table]
Statement [Table]
Number Of Employees Affected Due To Stock Option Repricing
Number of employees affected due to stock option repricing.
Stock option repricing, affected number of employees
Restricted Cash, Noncurrent
Restricted cash included in other noncurrent assets
Unrecognized Tax Benefits, Increase Resulting from Current Period Tax Positions
Additions based on tax positions related to current year
Operating lease right-of-use assets obtained in exchange for lease obligations
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Weighted-average grant-date fair value of options granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Offering Cost Included in Accounts Payable and Accrued Expenses and Other Current Liabilities
Offering cost included in accounts payable and accrued expenses and other current liabilities.
Offering cost included in accounts payable and accrued expenses and other current liabilities
Statement [Line Items]
Statement [Line Items]
Proceeds From Sales Of Marketable Securities
Proceeds from sales of marketable securities.
Proceeds from sales of marketable securities
Entity Filer Category
Entity Filer Category
Reclassification
Reclassification, Comparability Adjustment [Policy Text Block]
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Second Tranche
Debt Instrument, Redemption, Period Two [Member]
Liabilities and Equity
Total liabilities and stockholders' equity
Payments to Acquire Marketable Securities, Total
Payments to Acquire Marketable Securities
Purchases of marketable securities
Weighted-Average Exercise Price Per Share, Exercisable as of December 31, 2025
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Long-Lived Tangible Asset [Axis]
Long-Lived Tangible Asset
Fair Value, Liabilities Measured on Recurring Basis [Table Text Block]
Summary of Fair Value of Financial Assets Measured at Fair Value on Recurring Basis
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Increase in valuation allowance, deferred tax assets
Operating Loss Carryforwards [Table]
Operating Loss Carryforwards [Table]
Cybersecurity Risk Third Party Oversight and Identification Processes [Flag]
Deferred Tax Assets, Valuation Allowance, Total
Deferred Tax Assets, Valuation Allowance
Valuation allowance
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
U.S. federal taxes at statutory rate, Percent
Public offering price per unit
Shares Issued, Price Per Share
Subsequent Event [Line Items]
Cybersecurity Risk Management Third Party Engaged [Flag]
Documents Incorporated by Reference [Text Block]
Documents Incorporated by Reference
Other Noncash Income (Expense), Total
Other Noncash Income (Expense)
Other
Other
Grant Amount Received
Grant amount received.
Grant amount received
Effective Income Tax Rate Reconciliation, Percent
Total
Total, Percent
Investment Income, Interest
Interest income
Income Tax Jurisdiction [Axis]
Derivative Liability, Measurement Input
Measurement input
Proceeds from exercises of pre-funded warrants
Proceeds from Exercises of Pre-Funded Warrants
Proceeds from exercises of pre-funded warrants
Geographical [Domain]
Geographical
Number Of Shares Underlying Repriced Option
Number of shares underlying repriced option.
Number of shares underlying repriced option
Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block]
Restricted Cash
Disclosure of accounting policy for the risks and uncertainties during the reporting period.
Risk and Uncertainties [Policy Text Block]
Risks and Uncertainties
Tax credit carryforward domestic.
Tax Credit Carryforward Domestic
Tax credits, federal
Deferred Tax Assets, Property, Plant and Equipment
Property and equipment
Debt Instrument, Interest Rate During Period
Interest rate during period
Warrant issued to purchase shares of common stock
Warrant Issued to Purchase Shares of Common Stock
Warrant issued to purchase shares of common stock.
Organization and description of business.
Organization And Description Of Business [Line Items]
Organization And Description Of Business [Line Items]
Significant Accounting Policies [Text Block]
Summary of Significant Accounting Policies
Property, Plant and Equipment [Line Items]
Property Plant And Equipment [Line Items]
Vesting of early exercised stock options.
Vesting Of Early Exercised Stock Options
Vesting of early exercised stock options
Workforce Reduction
Workforce Reduction [Member]
Workforce reduction.
Granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Silicon Valley Bank Loan Agreement [Member]
Silicon Valley Bank Loan Agreement.
Silicon Valley Bank Loan Agreement
Cybersecurity Risk Management, Strategy, and Governance [Table]
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Amount [Abstract]
Nontaxable or nondeductible items
Earnings Per Share, Basic, Total
Earnings Per Share, Basic
Net loss per share, basic
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Shares, Outstanding Beginning Balance
Shares, Outstanding Ending Balance
Liabilities, Current
Total current liabilities
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract]
Adjustments to reconcile net loss to net cash used in operating activities:
2030
Lessee Operating Lease Liability Payments Due Year Five, Total
Lessee, Operating Lease, Liability, to be Paid, Year Five
Summary of Changes in Estimated Fair Value Liabilities Measures at Fair Value on a Recurring Basis
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]
Federal
Domestic Tax Jurisdiction [Member]
Effective Income Tax Rate Reconciliation, Tax Credit, Percent [Abstract]
Tax credits:
Unrecognized Tax Benefits, Increase Resulting from Prior Period Tax Positions
Additions based on tax positions related to prior years
Accounting Standards Update [Axis]
Accounting Standards Update
Additional office and laboratory space.
Additional Office And Laboratory Space [Member]
Additional Office and Laboratory Space
Consolidation Items [Domain]
Equity, Attributable to Parent [Abstract]
Stockholders' equity:
Entity Small Business
Entity Small Business
Retained Earnings (Accumulated Deficit), Ending Balance
Retained Earnings (Accumulated Deficit), Beginning Balance
Retained Earnings (Accumulated Deficit), Total
Retained Earnings (Accumulated Deficit)
Accumulated deficit
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-Based Compensation Cost
Stock-based compensation
Accounting Standards Update 2016-02 [Member]
ASC 842
Changes in unrecognized tax benefits
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Changes in Unrecognized Tax Benefits, Amount
Effective income tax rate reconciliation, nondeductible expense, changes in unrecognized tax benefits.
Changes in unrecognized tax benefits
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Cancelled
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Number of Options Outstanding, Options cancelled
Sale of Stock, Price Per Share
Common stock, per share
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value
Intrinsic value of options exercised
Share-Based Payment Arrangement [Text Block]
Stock-Based Compensation
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Amendment Flag
Amendment Flag
Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount
U.S. federal taxes at statutory rate
Organization and description of business.
Organization And Description Of Business [Table]
Organization And Description Of Business [Table]
Underwriting discounts and commissions.
Underwriting Discounts And Commissions
Underwriting discounts and commissions
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Warrants issued to purchase shares of common stock
Chief Executive Officer [Member]
Chief Executive Officer
Earnings Per Share, Policy [Policy Text Block]
Net Loss Per Share
Liabilities and Equity [Abstract]
LIABILITIES, CONVERTIBLE PREFERRED STOCK AND STOCKHOLDERS’ EQUITY (DEFICIT)
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation
Net cash used in operating activities
Increase (Decrease) in Operating Lease Liability
Operating lease liabilities
Borrowing Capacity of Term Loans
Borrowing capacity of term loans.
Borrowing capacity of term loans
Segment Reporting, CODM, Profit (Loss) Measure, How Used, Description
Milestone obligation additional extended payment term.
Milestone Obligation Additional Extended Payment Term
Milestone obligation additional extended payment terms
Common Stock [Member]
Common Stock
Cybersecurity Risk Role of Management [Text Block]
Tax credits
Tax Credit Carryforward, Amount
Lease expiration month and year end
Lease expiration month and year end
Lease expiration month and year, end
Granted
Weighted-average grant-date fair value of options granted
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
2028
Lessee, Operating Lease, Liability, to be Paid, Year Three
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Less: accumulated depreciation and amortization
Entity Address, Address Line One
Entity Address, Address Line One
Change in Accounting Principle, Accounting Standards Update, Immaterial Effect [true false]
Accounting standards update, immaterial effect [true false]
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Summary of Fair Value of Stock Option Awards
Fair Value Hierarchy and NAV [Axis]
Fair Value Hierarchy and NAV
Earnings Per Share [Abstract]
Income Tax, Policy [Policy Text Block]
Income Taxes
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Flag]
Statement of Financial Position Location, Balance [Axis]
Balance Sheet Location
Operating Lease, Right-of-Use Asset
Operating lease right-of-use assets
Pre funded warrant.
Pre Funded Warrant [Member]
Pre Funded Warrant
Deferred Tax Assets, Gross
Total deferred tax assets
Cybersecurity Risk Board Committee or Subcommittee Responsible for Oversight [Text Block]
Stock Issued During Period Value Issuance Of Warrant
Stock issued during period value issuance of warrant.
Issuance of warrant
Debt Instrument, Redemption, Period [Axis]
Summary of Net Operating Loss and Tax Carryforwards.
Summary Of Net Operating Loss And Tax Carryforwards Table [Text Block]
Summary of Net Operating Loss and Tax Carryforwards
Class of Warrant or Right [Axis]
Document Type
Document Type
Cash paid for income taxes
Income Taxes Paid, Net
Income Taxes Paid, Net, Total
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Convertible preferred stock tranche liability.
Convertible Preferred Stock Tranche Liability Policy [Text Block]
Convertible Preferred Stock Tranche Liability
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Collaborative Arrangement and Arrangement Other than Collaborative
Entity Central Index Key
Entity Central Index Key
Line of Credit Facility [Table]
Debt Securities, Available-for-Sale [Table Text Block]
Summary of Amortized Cost and Fair Value of Available for Sale Debt Securities
Sublease agreements expiration date.
Sublease Agreements Expiration Date
Sublease agreements expiration date
Cybersecurity Risk Process for Informing Board Committee or Subcommittee Responsible for Oversight [Text Block]
Lease initial expiration month and year
Lease initial expiration month and year
Lease initial expiration month and year.
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Including Exchange Rate Effect and Discontinued Operation
Net change in cash, cash equivalents and restricted cash
Subsequent Event Type [Domain]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Potentially dilutive securities were not included in the calculation of diluted net loss per share
Balance Sheet Related Disclosures [Abstract]
Commitments and contingencies.
Commitments And Contingencies [Table]
Commitments And Contingencies [Table]
Impairment of long lived assets
Impairment of Long-Lived Assets to be Disposed of
Common Stock, Par or Stated Value Per Share
Common stock, par value
Accounting Standards Update [Domain]
Accounting Standards Update
Summary of Prepaid Expenses and Other Current Assets
Schedule of Prepaid Expenses and Other Current Assets [Table Text Block]
Schedule of Prepaid Expenses and Other Current Assets.
Security Deposit
Security deposit
Operating Lease, Right-of-Use Asset, Periodic Reduction
Non-cash operating lease expense
Weighted-Average Remaining Contractual Life, Outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Weighted-Average Remaining Contractual Life, Outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Maximum
Expected volatility, maximum
Debt Securities, Available-for-Sale, Amortized Cost
Amortized Cost
Union City, California.
Union City California [Member]
Union City, California
Debt Securities, Available-for-sale, Total
Debt Securities, Available-for-Sale
Fair Value
Debt securities available-for-sale
Document Financial Statement Error Correction
Document Financial Statement Error Correction [Flag]
Operating Leases, Future Minimum Payments, Due in Four Years
2025
Exercised
Number of Options Outstanding, Options exercised
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Issuance of common stock upon exercise of stock options, shares
Shares Available for Further Issuance under Inducement Plan [Member]
Shares available for further issuance under inducement plan.
Shares Available for Further Issuance under the 2024 Inducement Equity Incentive Plan
Net Operating Losses Federal Expiration Year
Net operating losses federal expiration year
Net operating losses, federal expiration year
Estimates aggregate charges
Restructuring and Related Cost, Expected Cost
Restructuring and Related Cost, Expected Cost, Total
Debt Instrument, Redemption, Period Five [Member]
Final Tranche
Accrued research and development expenses.
Accrued Research And Development Expenses
Accrued research and development expenses
Accrued Liabilities, Current
Accrued and other current liabilities
Total accrued and other current liabilities
Current Fiscal Year End Date
Current Fiscal Year End Date
Series C convertible preferred stock.
Series C Convertible Preferred Stock [Member]
Series C Convertible Preferred Stock
Entity Address, State or Province
Entity Address, State or Province
Unvested as of December 31, 2025
Unvested as of December 31, 2024
Restricted stocks exercise of stock options, outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Stock Issued During Period, Value, Conversion of Convertible Securities
Issuance of common stock upon exercise of pre-funded warrants
Remaining amount available
Line of Credit Facility, Remaining Borrowing Capacity
Outstanding Lender Warrant
Outstanding Lender Warrant [Member]
Outstanding lender warrant.
Preferred Stock, Shares Outstanding, Ending Balance
Preferred Stock, Shares Outstanding, Beginning Balance
Preferred Stock, Shares Outstanding
Preferred stock, outstanding
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Comprehensive loss
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax
Unrealized Gain
Research and Development Expense, Policy [Policy Text Block]
Research and Development Expense
Common Stock, Capital Shares Reserved for Future Issuance
Common stock reserved for issuance
Series C preferred stock purchase agreement.
Series C Preferred Stock Purchase Agreement [Member]
Series C Preferred Stock Purchase Agreement
Non-refundable upfront license fee.
Non Refundable Upfront License Fee
Non-refundable upfront license fee
Class of Warrant or Right [Domain]
Geographical [Axis]
Geographical
Operating Leases, Future Minimum Payments, Due in Three Years
2024
Conversion of Stock, Shares Converted
Conversion of outstanding shares of convertible preferred stock
Increase (decrease) in prepaid expense and other current assets.
Increase Decrease In Prepaid Expense And Other Current Assets
Prepaid expenses and other current assets
State taxes (net of federal benefit)
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Amount
Summary of Stock-based Compensation
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Other
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Other, Amount
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Schedule of Deferred Income Taxes
Collaborative Arrangement Disclosure [Text Block]
License Agreements
Increase (decrease) in accrued liabilities and other current liabilities.
Increase Decrease In Accrued Liabilities And Other Current Liabilities
Accrued and other current liabilities
Proceeds from Sale and Maturity of Marketable Securities, Total
Proceeds from Sale and Maturity of Marketable Securities
Proceeds from maturities of marketable securities
Subsequent Events
Subsequent Event [Member]
Marketable Securities, Policy [Policy Text Block]
Marketable Securities
Issuance Of Common Stock And Warrants Value Net Of Issuance Costs
Issuance of common stock and warrants value net of issuance costs.
Issuance of common stock and warrants, net of issuance costs
Other noncurrent assets
Other Assets, Noncurrent, Total
Other Assets, Noncurrent
Term to Valuation Date
Measurement Input, Expected Term [Member]
Proceeds from Issuance of Convertible Preferred Stock
Proceeds from issuance of Series C convertible preferred stock, net of issuance costs
Proceeds from issuance of convertible preferred stock, net of issuance costs
Number of lessee lease renewal term.
Number Of Lease Renewal Term
Number of lease renewal term
Antidilutive Securities [Axis]
Antidilutive Securities
Operating Loss Carryforwards [Line Items]
Operating Loss Carryforwards [Line Items]
Follow-On Offering
Follow-On Offering.
Follow-On Offering [Member]
Follow On Offering
State
State and Local Jurisdiction [Member]
AOCI Attributable to Parent [Member]
Accumulated Other Comprehensive Income (Loss)
Issuance of common stock upon exercise of warrants
Issuance Of Common Stock Upon Exercise Of Warrants Value
Issuance of common stock upon exercise of warrants value.
Lessee, Operating Lease, Option to Extend
Lease, option to extend
Preferred stock, $0.0001 par value; 200,000,000 shares authorized as of December 31, 2025 and 2024; no shares issued and outstanding as of December 31, 2025 and 2024
Preferred Stock, Value, Issued, Ending Balance
Preferred Stock, Value, Issued, Beginning Balance
Preferred Stock, Value, Issued, Total
Preferred Stock, Value, Issued
Convertible preferred stock tranche liability.
Convertible Preferred Stock Tranche Liability [Member]
Convertible Preferred Stock Tranche Liability
Minimum [Member]
Minimum
Clinical [Member]
Clinical.
Clinical
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Granted
Assets, Current [Abstract]
Current assets:
Series A Warrant [Member]
Series a warrant.
Series A Warrant
Reconciliation of Operating Profit (Loss) from Segments to Consolidated [Table]
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Including Discontinued Operation [Abstract]
Components of cash, cash equivalents and restricted cash:
Level 3
Fair Value, Inputs, Level 3 [Member]
Segment Reporting [Abstract]
Deferred Tax Liabilities, Property, Plant and Equipment
Property and equipment
Property and equipment
Tax Period [Domain]
Tax Period
Liabilities, Current [Abstract]
Current liabilities:
Restructuring and Related Activities Disclosure [Text Block]
Workforce Reduction
Related Party Transactions [Abstract]
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals, Accrued Liabilities
Accrued expenses and other
Shares, Outstanding
Balance, shares
Balance, shares
Sublease Income
Sublease Income
Net operating losses
Operating Loss Carryforwards
Operating Loss Carryforwards, Total
Lessee, Operating Lease, Renewal Term
Lease renewal term
Commitments and Contingencies
Commitments and contingencies (Note 4)
Lessee, Leases [Policy Text Block]
Leases
Unvested as of December 31, 2025
Unvested as of December 31, 2024
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
License agreements.
License Agreements [Abstract]
General and Administrative
General and Administrative Expense [Member]
Total operating lease liabilities
Total operating lease liabilities
Operating Lease, Liability
Operating lease liabilities
Auditor Firm ID
Auditor Firm ID
Net Operating Losses State Expiration Year
Net operating losses state expiration year
Net operating losses, state expiration year
Line of Credit Facility [Abstract]
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Change in valuation allowance
Change in valuation allowance, Percent
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Outstanding, Weighted Average Remaining Contractual Terms
Weighted-Average Remaining Contractual Life, Unvested
Lender Warrant [Member]
Lender warrant.
Lender Warrant
Capital Expenditures Incurred but Not yet Paid
Property and equipment included in accounts payable and accrued and other current liabilities
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Net loss
Debt Instrument, Maturity Date Range, Start
Commence Date
Cybersecurity Risk Management Positions or Committees Responsible [Text Block]
Weighted Average Number of Shares Outstanding, Basic, Total
Weighted Average Number of Shares Outstanding, Basic
Weighted-average shares used in computing net loss per share, basic
Aggregate Intrinsic Value, Exercisable as of December 31, 2025
Intrinsic value of options exercised
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Number of additional option to extend milestone payment.
Number Of Additional Option To Extend Milestone Payment
Number of additional option to extend milestone payment
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Schedule of Effective Tax Rate Reconciliation
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Issuance Of Common Stock And Warrants Net of Issuance Costs Shares
Issuance of common stock and warrants net of issuance costs shares.
Issuance of common stock and warrants, net of issuance costs, shares
Long-Lived Tangible Asset [Domain]
Long-Lived Tangible Asset
Cybersecurity Risk Process for Informing Management or Committees Responsible [Text Block]
Deferred Tax Assets, Net [Abstract]
Deferred tax assets:
Subsequent Events [Text Block]
Subsequent Events
Effective Income Tax Rate Reconciliation, Tax Credit, Percent
Effective Income Tax Rate Reconciliation, Tax Credit, Percent, Total
Credits, Percent
Credits, Percent
Related Party Transactions Disclosure [Text Block]
Related Party Transactions
CIRM Grant
California Institute for Regenerative Medicine Grant [Policy Text Block]
California institute for regenerative medicine grant.
APIC, Share-based Payment Arrangement, Increase for Cost Recognition, Total
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Stock-based compensation
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount
Change in valuation allowance
Equity, Attributable to Parent
Balance
Balance
Total stockholders' equity
Net operating losses, federal expiration begin year
Net Operating Losses, Federal Expiration Begin Year
Net operating losses, federal expiration begin year.
Preferred Stock, Par or Stated Value Per Share
Preferred stock, par value
Basis of Accounting, Policy [Policy Text Block]
Basis of Presentation
Lessee, Operating Lease, Existence of Option to Extend [true false]
Statement of Stockholders' Equity [Abstract]
Cash Equivalents [Member]
Cash Equivalents
Use of Estimates, Policy [Policy Text Block]
Use of Estimates
Outstanding December 2025 Warrants [Member]
Outstanding december 2025 warrants.
Outstanding December 2025 Warrants
Leasehold Improvements [Member]
Leasehold Improvements
Entity Address, Address Line Two
Entity Address, Address Line Two
Fair Value Disclosures [Text Block]
Fair Value Measurements
Share-Based Compensation Arrangement by Share-Based Payment Award, Discount from Market Price, Purchase Date
Participants to purchase shares through payroll deduction at lower percentage of fair market value
Tax credits, federal expiration begin year
Tax Credits, Federal Expiration Begin Year
Tax credits, federal expiration begin year.
Debt Instrument, Name [Domain]
Other current assets
Other Assets, Current
Other current assets
Measurement Input, Discount Rate [Member]
Discount rate
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]
Schedule of Unrecognized Tax Benefits
Segment Reporting, CODM, Individual Title and Position or Group Name [Extensible Enumeration]
2021 Equity Incentive Plan
Two thousand and twenty one equity incentive plan.
Two Thousand And Twenty One Equity Incentive Plan [Member]
Milestone payments contingent upon achieving specific clinical and commercialization milestone events.
Milestone Payments Contingent Upon Achieving Specific Clinical And Commercialization Milestone Events
Milestone payments for royalty-bearing products contingent upon achieving specific clinical and commercialization milestone events
Plan Name [Domain]
Plan Name
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Settlements
Settlement of convertible preferred stock tranche liability on second and third closings of the Series B convertible preferred stock
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Credit Facility [Axis]
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Text Block]
Receivables from Stockholder [Member]
Notes Receivable from Stockholders
Cybersecurity Risk Management Expertise of Management Responsible [Text Block]
Debt Securities [Member]
Marketable Securities
Tax Period [Axis]
Tax Period
Other Noncurrent Assets
Other Noncurrent Assets [Member]
Number Of Option Remaining To Extend The Lease Term
Number of option remaining to extend the lease term.
Number of option remaining to extend the lease term | Option
Accrued Income Taxes
Accrued Income Taxes, Total
Accrued taxes
Restructuring Plan [Axis]
Property, Plant and Equipment, Policy [Policy Text Block]
Property and Equipment, Net
Entity Address, City or Town
Entity Address, City or Town
Shares available for further issuance under the 2021 Employee Stock Purchase Plan member
Shares available for further issuance under the 2021 Employee Stock Purchase Plan member
Shares Available for Further Issuance under the 2021 Employee Stock Purchase Plan
Number of reportable segment
Number of Reportable Segments
Security Exchange Name
Security Exchange Name
Credit Facility [Domain]
Lease Expiration month and year.
Lease Expiration Month And Year
Lease expiration month and year
Long-Term Debt, Gross
Funds under loan agreement
Property, Plant and Equipment, Gross, Ending Balance
Property, Plant and Equipment, Gross, Beginning Balance
Property, Plant and Equipment, Gross, Total
Property, Plant and Equipment, Gross
Total property and equipment
Counterparty Name [Axis]
Counterparty Name
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest
Net loss before income tax expense
Significant accounting policies.
Significant Accounting Policies [Table]
Significant Accounting Policies [Table]
Upfront Payments Received
Upfront payments received.
Upfront payment
Measurement Input Type [Domain]
Measurement Input Type
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name
Other offering expenses.
Other Offering Expenses
Other offering expenses
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Ending Balance
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Beginning Balance
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation
Cash, cash equivalents and restricted cash
Statistical Measurement [Domain]
Statistical Measurement
Class of Warrant or Right, Exercise Price of Warrants or Rights
Warrants, exercise price
Assets, Current
Total current assets
Total stock-based compensation
Share-Based Payment Arrangement, Expense
Stock-based compensation
Document Period End Date
Document Period End Date
At the market sales agreement.
At The Market Sales Agreement [Member]
At-the-Market Equity Offering
Title and Position [Axis]
Fair Value Hierarchy and NAV [Domain]
Fair Value Hierarchy and NAV
Effective Income Tax Rate Reconciliation, Tax Credit,Orphan drug credit,Percent
Effective income tax rate reconciliation, tax credit,orphan drug credit.
Orphan drug credit, Percent
Orphan drug credit, Percent
ICFR Auditor Attestation Flag
ICFR Auditor Attestation Flag
Shares, Exercisable as of December 31, 2025
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Temporary equity share purchase price per share.
Temporary Equity Share Purchase Price Per Share
Convertible preferred stock purchase price per share
Commissions and Offering Costs
Commissions and offering costs.
Commissions and offering costs
Statement of Financial Position [Abstract]
Antidilutive Security, Excluded EPS Calculation [Table]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Other comprehensive income (loss):
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract]
Class of Stock [Axis]
Class of Stock
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items]
Participants to purchase common stock through payroll deduction annual limit of eligible compensation.
Participants To Purchase Common Stock Through Payroll Deduction Annual Limit Of Eligible Compensation
Participants to purchase common stock through payroll deduction annual limit of eligible compensation
Outstanding Series A And B Warrants [Member]
Outstanding series A and B warrants.
Outstanding Series A And B Warrants
Cybersecurity Risk Management, Strategy, and Governance [Line Items]
Warrants and Rights Outstanding, Maturity Date
Warrants expires date
Commercial Paper, Not Included with Cash and Cash Equivalents [Member]
Commercial Paper
Liabilities
Total liabilities
2027
Lessee, Operating Lease, Liability, to be Paid, Year Two
Restricted Stock [Member]
Restricted Stock
Restricted Stock Subject to Future Vesting
Weighted Average Number of Shares Outstanding, Diluted, Total
Weighted Average Number of Shares Outstanding, Diluted
Weighted-average shares used in computing net loss per share, diluted
Securities Act File Number
Entity File Number
Net unrealized (loss) gain on marketable securities
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Issuance of common stock and pre-funded warrants, net of issuance costs
Issurance Of Common Stock And Pre - Funded Warrants Value Net Of Issuance Costs
Issurance of common stock and pre - funded warrants value net of issuance costs.
ASU 2023-07
Accounting Standards Update 2023-07 [Member]
Cover [Abstract]
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Minimum
Expected volatility, minimum
Measurement Input Type [Axis]
Measurement Input Type
Share based compensation arrangement by share based payment award number of shares that may be issued in accordance with the plan.
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares That May Be Issued In Accordance With Plan
Number of shares of common stock that may be issued in accordance with the plan
Total prepaid expenses and other current assets
Prepaid Expense and Other Assets, Current
Prepaid expenses and other current assets
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Forfeited
Supplemental Balance Sheet Disclosures [Text Block]
Balance Sheet Components
Significant accounting policies.
Significant Accounting Policies [Line Items]
Significant Accounting Policies [Line Items]
US Treasury Securities [Member]
U.S. Treasuries
Number of Operating Segments
Number of operating segment
Sale of Stock [Domain]
Sale of Stock
Segment Reporting Disclosure [Text Block]
Segment Reporting
General and Administrative Expense, Total
General and Administrative Expense
General and administrative
Number of share exercisable
Class Of Warrant Or Right, Number Of Securities ExercisableClass Of Warrant Or Right, Number Of Securities Exercisable
Class of warrant or right, number of securities exercisable.
Subsequent Event [Table]
Percentage of shares of common stock outstanding on last day of immediately preceding year.
Percentage Of Shares Of Common Stock Outstanding On Last Day Of Immediately Preceding Year
Percentage of shares of common stock outstanding on last day of immediately preceding year
Office and laboratory space.
Office And Laboratory Space [Member]
Office and Laboratory Space
Operating Lease, Expense
Rent expense
Property, Plant and Equipment, Useful Life
Property and equipment, useful life
New Accounting Pronouncements, Policy [Policy Text Block]
Recently Adopted Accounting Standards and Recently Issued Accounting Pronouncements Not Yet Adopted
Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block]
Summary of Future Minimum Lease Payments Under Operating Lease
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Stock Issued During Period, Shares, Conversion of Convertible Securities
Issuance of common stock upon exercise of pre-funded warrants, shares
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Other, Percent
Other, Percent
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Vesting period
Share Based Compensation Arrangement By Share Based Payment Award Options Exercise Price Per Share
Share based compensation arrangement by share based payment award options exercise price per share.
Per share exercise price of eligible stock option awards
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Minimum
Risk-free interest rate, minimum
Share-Based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount
Unrecognized stock-based compensation cost
Lessee Operating Tenant Improvement Receivable, Total
Lessee Operating Tenant Improvement Receivable.
Lessee Operating Tenant Improvement Receivable
Tenant improvement receivable
Lessee, Operating Lease, Term of Contract
Term of lease
Long-Term Investments, Total
Long-Term Investments
Long-term investments in marketable securities
Common Stock, Shares, Outstanding, Ending Balance
Common Stock, Shares, Outstanding, Beginning Balance
Common Stock, Shares, Outstanding
Common stock, outstanding
Operating Lease, Liability, Current
Operating lease liabilities, current
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Emerging growth company status.
Emerging Growth Company Status Policy [Text Block]
Emerging Growth Company Status
Depreciation, Depletion and Amortization, Total
Depreciation, Depletion and Amortization
Depreciation and amortization
Cybersecurity Risk Management Processes Integrated [Flag]
Document Transition Report
Net deferred tax assets
Deferred Tax Assets, Net
Short-Term Investments, Total
Short-Term Investments
Short-term investments in marketable securities
Operating Expenses
Total operating expenses
Research and development expense related to upfront license fee payable
Research and Development Expense
Research and development
Total Research and development
Schedule of Common Stock Reserved for Issuance
Schedule of common stock reserved for issuance.
Schedule Of Common Stock Reserved For Issuance Table [Text Block]
Convertible Preferred Stock [Member]
Convertible Preferred Stock
Deferred Tax Assets, Operating Loss Carryforwards, State and Local
Net operating losses, state
Statement of Cash Flows [Abstract]
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Weighted Average Grant Date Fair Value per Share
Issuance of common stock value
Issuance of common stock in connection with at-the-market sales, net of issuance costs
Stock Issued During Period, Value, New Issues
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Summary of Stock Option Activity
Issuance of common stock upon exercise of stock options and vesting of restricted stock units
Stock Issued During Period Value Stock Options Exercised And Vesting Of Restricted Stock Units
Stock issued during period value stock options exercised and vesting of restricted stock units.
Operating Leases, Future Minimum Payments Due, Next 12 Months
2022
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Percent
Stock-based compensation, Percent
Stock-based compensation, Percent
Stockholders' Equity
Equity [Text Block]
Gladstone.
Gladstone [Member]
Gladstone
Second Amendment
Second Amendment Member
Second Amendment Member.
Annual license maintenance fees.
Annual License Maintenance Fees
Annual license maintenance fees
Earnings Per Share [Text Block]
Net Loss Per Share
Temporary Equity [Line Items]
Temporary Equity [Line Items]
Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block]
Summary of Restricted Stock Activity
Computer Equipment [Member]
Computer Equipment and Software
Cybersecurity Risk Management Processes Integrated [Text Block]
Net loss
Net loss
Net loss
Gladstone license agreement
Gladstone License Agreement [Member]
Gladstone License Agreement
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Aggregate Intrinsic Value, Outstanding
Issuance of common stock upon exercise of warrants, shares
Issuance Of Common Stock Upon Exercise Of Warrants Share
Issuance of common stock upon exercise of warrants share.
Deferred tax assets deferred expense capitalized research and development costs.
Deferred Tax Assets Deferred Expense Capitalized Research And Development Costs
Capitalized research and development expenditure
Operating Lease, Cost
Operating lease cost
Warrants and Rights Outstanding, Term
Warrant expiration term
Tax credit receivable
Income Taxes Receivable, Current
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Expected dividend yield
Line of Credit Facility [Line Items]
Tax credits, federal expiration year
Tax Credits Federal Expiration Year
Tax credits federal expiration year
Operating Lease, Payments
Cash paid for amounts included in the measurement of lease liabilities
Assets [Abstract]
ASSETS
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Risk-free interest rate
Construction in Progress [Member]
Construction in Progress
Restructuring and Related Activities [Abstract]
Document Fiscal Year Focus
Document Fiscal Year Focus
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract]
Cash flows from investing activities:
Accounts Payable, Current, Total
Accounts Payable, Current
Accounts payable
Research and Development
Research and Development Expense [Member]
Research
Increase (Decrease) in Other Noncurrent Assets
Other noncurrent assets
Restructuring Cost and Reserve [Line Items]
Fair Value Measurement, Policy [Policy Text Block]
Fair Value Measurements
Class of warrant or right exercise price of warrants or rights1 price per share.
Class Of Warrant Or Right Exercise Price Of Warrants Or Rights1 Price Per Share
Class of warrant price per share
Class Of Warrant Or Right Number Of Securities Exercisable Class Of Warrant Or Right Additional Number Of Securities Exercisable
Class of warrant or right number of securities exercisable class of warrant or right additional number of securities exercisable.
Additional warrants exercisable
Temporary Equity Disclosure [Abstract]
Fair Value Disclosures [Abstract]
Commitments and Contingencies Disclosure [Abstract]
Net operating losses, federal expiration description
Net Operating Losses, Federal Expiration Description
Net operating losses, federal expiration description.
2026
Lessee, Operating Lease, Liability, to be Paid, Year One
Outstanding Stock Options And Restricted Stock Units [Member]
Outstanding stock options and restricted stock units.
Outstanding Stock Options and Restricted Stock Units
Number of closings.
Number Of Closings
Number of closings
Debt Instrument [Axis]
Lessee Operating Lease Liability Payments Due After Year Five, Total
Lessee, Operating Lease, Liability, to be Paid, after Year Five
Thereafter
Share-Based Payment Arrangement [Abstract]
Sale of Stock [Axis]
Sale of Stock
Reductions in Upfront Payment When Nominated Targets That Do not Meet Certain Agreed-upon Standards
Reductions in upfront payment when nominated targets that do not meet certain agreed-upon standards.
Upfront payment reductions for nominated targets that do not meet certain agreed-upon standards
Net cash provided by investing activities
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation
Title of 12(b) Security
Title of 12(b) Security
Deferred tax liabilities:
Deferred Tax Liabilities, Net [Abstract]
ATM Facility
ATM Facility [Member]
ATM Facility.
U.S. Treasuries
US Treasury Securities Not Included With Cash And Cash Equivalents [Member]
US treasury securities, not Included with cash and cash equivalents.
Deferred tax assets removed related to net operating loss carryforwards and research tax credit carryforwards.
Deferred Tax Assets Removed Related To Net Operating Loss Carryforwards And Research Tax Credit Carryforwards
Deferred tax assets removed related to net operating loss carryforwards and research tax credit
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Amount
Stock-based compensation
Cancelled
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Forfeited
Money Market Funds [Member]
Money Market Funds
Twenty Twenty Four Inducement Equity Incentive Plan [Member]
Twenty twenty four inducement equity incentive plan.
2024 Inducement Equity Incentive Plan
Income Tax Disclosure [Text Block]
Income Taxes
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table]
Convertible preferred stock shares issued
Temporary Equity, Shares Issued
Shares Issued
After December Thirty One Two Thousand and Seventeen.
After December Thirty One Two Thousand And Seventeen [Member]
Post-December 31, 2017
Extension Date
Debt Instrument, Maturity Date Range, End
Other Liabilities, Noncurrent, Total
Other Liabilities, Noncurrent
Other noncurrent liabilities
Debt Instrument, Redemption, Period [Domain]
Restructuring Plan [Domain]
Offering expenses
Offering Expenses
Offering expenses.
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract]
Changes in operating assets and liabilities:
Property, Plant and Equipment [Table Text Block]
Summary of Property and Equipment, Net
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Weighted-Average Exercise Price Per Share, Outstanding Ending Balance
Weighted-Average Exercise Price Per Share, Outstanding Beginning Balance
Stock options exercise price per share
Income Tax Disclosure [Abstract]
Maximum aggregate offering price.
Maximum Aggregate Offering Price
Maximum aggregate offering price
Fair Value, Recurring and Nonrecurring [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
University of Texas Southwestern License Agreement
University of Texas southwestern license agreement.
University Of Texas Southwestern License Agreement [Member]
Unrecognized Tax Benefits
Balance at end of year
Balance at beginning of year
Additional Paid-in Capital [Member]
Additional Paid-In Capital
Measurement Frequency [Domain]
Statement of Income Location, Balance [Axis]
Income Statement Location
Warrant exercisable percentage
Class of Warrant or Right Number Of Securities Exercisable Percentage
Class of warrant or right number of securities exercisable percentage.
Accounting standards update, adoption date
Change in Accounting Principle, Accounting Standards Update, Adoption Date
Trading Symbol
Trading Symbol
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Maximum
Risk free interest rate, maximum
Maximum Borrowing Capacity of Term Loans
Maximum borrowing capacity of term loans.
Maximum borrowing capacity of term loans
Debt Instrument, Redemption, Period Three [Member]
Third Tranche
Subsequent Event Type [Axis]
Before January 1, 2018.
Before January One Two Thousand And Eighteen [Member]
Pre-January 1, 2018
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract]
Cash flows from financing activities:
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Expected term (in years)
Fair Value, Measurements, Recurring
Fair Value, Recurring [Member]
Entity Ex Transition Period
Entity Ex Transition Period
Lessee, Operating Lease, Liability, to be Paid
Total undiscounted future minimum lease payments
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Imputed interest
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Percent
Research and development, Percent
Research and development, Percent
Equity Components [Axis]
Equity Components
Operating Leases, Future Minimum Payments, Due in Two Years
2023
Total other income, net
Nonoperating Income (Expense)
Equity Component [Domain]
Equity Component
Asset Class [Axis]
Schedule of Future Minimum Rental Payments for Operating Leases [Table Text Block]
Summary of Undiscounted Future Minimum Lease Payments Due Under Non-cancelable Operating Lease
Tax credit carryforward state.
Tax Credit Carryforward State
Tax credits, state
Document Annual Report
IPO [Member]
Initial Public Offering
Accrued compensation and related expenses.
Accrued Compensation And Related Expenses
Accrued compensation and related expenses
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Issuance of common stock pursuant to employee stock purchase plan, shares
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period
Common stock shares available for issuance period
Depreciation, Depletion and Amortization, Nonproduction, Total
Depreciation, Depletion and Amortization, Nonproduction
Depreciation and amortization expense
Common Stock, Voting Rights
Common stock voting rights
Deferred Tax Assets, Operating Loss Carryforwards, Domestic
Net operating losses, federal (post-December 31, 2017)
Shares available for further issuance under the 2021 Equity Incentive Plan member
Shares available for further issuance under the 2021 Equity Incentive Plan member
Shares Available for Further Issuance under the 2021 Equity Incentive Plan
Maximum [Member]
Maximum
Statistical Measurement [Axis]
Statistical Measurement
Exercised
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Prepaid expenses
Prepaid Expense, Current
Prepaid Expense, Current, Total
Common stock, $0.0001 par value; 1,000,000,000 shares authorized as of December 31, 2025 and 2024; 216,760,283 and 86,542,340 shares issued and outstanding as of December 31, 2025 and 2024
Common Stock, Value, Issued, Ending Balance
Common Stock, Value, Issued, Beginning Balance
Common Stock, Value, Issued, Total
Common Stock, Value, Issued
Line of Credit Facility, Expiration Date
Expired date
Equipment [Member]
Laboratory Equipment
Available for sale securities debt maturities one and two years fair value.
Available For Sale Securities Debt Maturities One And Two Years Fair Value
Available-for-sale marketable securities maturities between one and two years
Deferred Tax Assets, Operating Loss Carryforwards, Total
Deferred Tax Assets, Operating Loss Carryforwards
Net operating losses
Cybersecurity Risk Management Processes for Assessing, Identifying, and Managing Threats [Text Block]
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Impairment for Long-Lived Assets
Participants to purchase common stock through payroll deduction maximum percentage of eligible compensation.
Participants To Purchase Common Stock Through Payroll Deduction Maximum Percentage Of Eligible Compensation
Participants to purchase common stock through payroll deduction maximum percentage of eligible compensation
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent
State taxes (net of federal benefit), Percent
Entity Public Float
Entity Public Float
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Expected volatility
Preferred Stock, Shares Authorized
Preferred stock, authorized
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Changes In Unrecognized Tax Benefits, Percent
Effective income tax rate reconciliation, nondeductible expense, changes in unrecognized tax benefits.
Changes in unrecognized tax benefits, Percent
Changes in unrecognized tax benefits, Percent
Milestone and royalty payments.
Milestone And Royalty Payments
Milestone and royalty payments recognized
Amortization of premium on marketable securities
Amortization Of Premium On Marketable Securities
Amortization Of Premium On Marketable Securities
Amortization (accretion) of premium (discount) on marketable securities
Manufacturing Equipment
Manufacturing Facility [Member]
2021 Employee Stock Purchase Plan
Employee Stock [Member]
Entity Registrant Name
Entity Registrant Name
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued, Total
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued
Accrued interest and penalties related to unrecognized tax benefits
Term Loan
Debt Disclosure [Text Block]
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax
Unrealized Loss
Entity Voluntary Filers
Entity Voluntary Filers
Other income, net
Other income (expense), net
Other Nonoperating Income (Expense), Total
Other Nonoperating Income (Expense)
Additional Paid in Capital, Ending Balance
Additional Paid in Capital, Beginning Balance
Additional Paid in Capital, Total
Additional Paid in Capital
Additional paid-in capital
Subsequent Events [Abstract]
December Two Thousand Twenty Five Warrant [Member]
December 2025 warrant.
December 2025 Warrant
Cybersecurity Risk Management Positions or Committees Responsible [Flag]
Total
Income taxes expense
Income Tax Expense (Benefit)
Income tax expense
Income tax expense
Measurement Frequency [Axis]
Proceeds from exercises of pre-funded warrants
Proceeds from issuance of common stock at the market
Proceeds from at-the-market sales, net of issuance costs
Tenant improvement allowance.
Tenant Improvement Allowance
Tenant improvement allowance
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Fair Value Measurement Inputs and Valuation Techniques [Table Text Block]
Summary of Significant Unobservable Assumptions used to Convertible Preferred Stock Tranche Liability
Alnylam Pharmaceuticals, Inc.
Alnylam Pharmaceuticals, Inc. [Member]
Alnylam Pharmaceuticals, Inc.
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Concentration of Credit Risk
Lessee, Operating Lease, Remaining Lease Term
Weighted-average remaining lease term
Liability Class [Axis]
Liability Class
Other
Other [Member]
Other.
Accumulated other comprehensive income
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Accumulated Other Comprehensive Income (Loss), Net of Tax
Consolidation Items [Axis]
Outstanding stock options and awards
Outstanding Stock Options and Awards [Member]
Outstanding Stock Options and Awards
Payments to Acquire Property, Plant, and Equipment, Total
Payments to Acquire Property, Plant, and Equipment
Purchases of property and equipment
Payment for (Proceeds from) Other Investing Activity
Other
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Granted
Series B Warrant
Series B Warrant [Member]
Series b warrant.
Temporary Equity, by Class of Stock [Table]
Temporary Equity By Class Of Stock [Table]
Assets
Total assets
Property, Plant and Equipment [Table]
Schedule Of Property Plant And Equipment [Table]
Weighted-Average Remaining Contractual Life, Exercisable as of December 31, 2025
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Income Statement [Abstract]
Collaboration Agreement
Collaborative Arrangement, Transaction with Party to Collaborative Arrangement [Member]
Grant Awarded Upon Achievement Of Milestones Based On Clinical Trials
Grant awarded upon achievement of milestones based on clinical trials.
Grant awarded upon achievement of milestones
Restructuring Cost [Table]
Unrecognized Tax Benefits, Decrease Resulting from Prior Period Tax Positions
Reductions for tax positions related to prior years
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Aggregate Intrinsic Value, Outstanding
Aggregate Intrinsic Value, Unvested
Share-Based Payment Arrangement [Policy Text Block]
Stock-Based Compensation
Milestone obligation amount.
Milestone Obligation Amount
Milestone obligation amount
First Tranche
Debt Instrument, Redemption, Period One [Member]
Issuance of warrant in connect with Loan Agreement.
Issuance of Warrant in Connect With Loan Agreement
Issuance of warrant in connection with Loan Agreement
Sale of Stock, Number of Shares Issued in Transaction
Number of common shares
Number of units completed
Debt Instrument, Redemption, Period Four [Member]
Fourth Tranche
Issuance of common stock in connection with at-the-market sales, net of issuance costs, shares
Issuance of common stock
Stock Issued During Period, Shares, New Issues
Convertible preferred stock, shares authorized
Shares Authorized
Temporary Equity, Shares Authorized
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Vested
Vested
Earnings Per Share, Diluted, Total
Earnings Per Share, Diluted
Net loss per share, diluted
Schedule of Segment Reporting Information, by Segment [Table Text Block]
Schedule of Operating Expenses by Function
Operating Segments [Member]
Operating Segments
Title and Position [Domain]
City Area Code
City Area Code
Other Comprehensive Income (Loss), Net of Tax, Total
Other Comprehensive Income (Loss), Net of Tax
Other comprehensive income
Auditor Name
Auditor Name
Lessee operating lease commenced.
Lessee Operating Lease Commenced
Lease commenced month and year
Deferred Tax Assets, Tax Credit Carryforwards, Total
Deferred Tax Assets, Tax Credit Carryforwards
Tax credits
Counterparty Name [Domain]
Counterparty Name
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Amount
Research and development
Research and development
Variable Lease, Cost
Variable lease cost
Stock Issued During Period, Value, Employee Stock Purchase Plan
Issuance of common stock pursuant to employee stock purchase plan
Operating Lease, Weighted Average Remaining Lease Term
Weighted-average remaining lease term
Lease Expiration Date
Lease Expiration Date
Lease, Cost
Total lease cost
Cash and Cash Equivalents, Policy [Policy Text Block]
Cash and Cash Equivalents
Property, Plant and Equipment, Net, Ending Balance
Property, Plant and Equipment, Net, Beginning Balance
Property, Plant and Equipment, Net
Property and equipment, net
Total property and equipment, net
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Including Discontinued Operation
Cash and cash equivalents and restricted cash at end of period
Cash and cash equivalents and restricted cash at beginning of period
Operating Income (Loss)
Loss from operations
Proceeds from exercise of stock options and employee stock purchase plan
Proceeds from Exercise of Stock Options and Employee Stock Purchase Plan
Proceeds from exercise of stock options and employee stock purchase plan
Retained Earnings [Member]
Accumulated Deficit
Net operating losses, state expiration begin year
Net Operating Losses, State Expiration Begin Year
Net Operating Losses, State Expiration Begin Year
Incremental Stock-based compensation expense
Employee Benefits and Share-Based Compensation
Share-based Payment Arrangement, Noncash Expense, Total
Share-Based Payment Arrangement, Noncash Expense
Stock-based compensation
Payment of accrued offering costs
Payment of accrued offering costs
Payments of Stock Issuance Costs
Stock issuance costs
Incremental Stock-based compensation expense vested repriced options
Employee Benefits And Share Based Compensation Vested Repriced Options
Employee benefits and share based compensation vested repriced options.
Operating Lease, Weighted Average Discount Rate, Percent
Weighted-average discount rate
Operating Lease, Liability, Noncurrent
Operating lease liabilities, noncurrent
Fair Value, Inputs, Level 1 [Member]
Level 1
Class of Stock [Line Items]
Class of Stock [Line Items]
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation
Net cash provided by financing activities
Lease, Cost [Table Text Block]
Summary of Operating Lease Activity
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent [Abstract]
Nontaxable or nondeductible items
Change in Accounting Principle, Accounting Standards Update, Adopted [true false]
Accounting standards update, adopted [true false]
Issuance of common stock and pre-funded warrants, net of issuance costs, shares.
Issuance Of Common Stock And Pre-funded Warrants, Net Of Issuance Costs, Shares
Issuance of common stock and pre-funded warrants, net of issuance costs, shares
Auditor Location
Auditor Location
Other income, net:
Nonoperating Income (Expense) [Abstract]
US Government Corporations and Agencies Securities [Member]
Government Agencies Bonds
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Schedule of Antidilutive Securities Excluded from Computation of Diluted Net Loss Per Share
Corporate Debt Securities [Member]
Corporate Bonds
Income Tax Jurisdiction [Domain]
Entity Interactive Data Current
Entity Interactive Data Current
Statement of Income Location, Balance [Domain]
Income Statement Location
Right-of-use asset
Right-of-use asset
Deferred Tax Liabilities, Right-of-Use Asset
Deferred tax liabilities, right-of-use asset.
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract]
Cash flows from operating activities:
Furniture and Fixtures [Member]
Furniture and Fixtures
Milestone payments contingent upon achieving specific development and commercialization milestone events.
Milestone Payments Contingent Upon Achieving Specific Development And Commercialization Milestone Events
Milestone payments contingent upon achieving specific development and commercialization milestone events
Tax credits, state expiration description
Tax Credits, State Expiration Description
Tax credits, state expiration description.
Underwritten Offering [Member]
Underwritten offering.
Underwritten Offering
Increase (Decrease) in Other Noncurrent Liabilities
Other noncurrent liabilities
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Gain (Loss) Included in Earnings
Change in fair value upon remeasurement
Stock option repricing impact in stock option awards
Stock Options Repricing Impact In Stock Option Award
Stock options repricing impact in stock option award.
Stock option repricing impact in stock option awards
Line of Credit Facility, Current Borrowing Capacity
Current loan amount available
Entity Tax Identification Number
Entity Tax Identification Number
Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]
Organization and Description of the Business
Proceeds from Issuance or Sale of Equity, Total
Proceeds from Issuance or Sale of Equity
Proceeds from issuance of equity, net of issuance costs
Local Phone Number
Local Phone Number
Other Liabilities, Current, Total
Other Liabilities, Current
Other current liabilities
Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Unrecognized stock-based compensation
Short-Term Lease, Cost
Short-term lease cost
Auditor Opinion [Text Block]
Accounting Policies [Abstract]
Partial settlement of stock, tranche liability.
Partial Settlement Of Stock Tranche Liability
Partial settlement of stock, tranche liability
2029
Lessee, Operating Lease, Liability, to be Paid, Year Four
Cash and Cash Equivalents [Member]
Class of Stock [Domain]
Class of Stock
Total future minimum lease payments
Operating Leases, Future Minimum Payments Due
Commercial Paper [Member]
Commercial Paper
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Shares reserved and available for grant
weighted-average period
Unrecognized stock-based compensation cost, weighted-average recognition period
Offering period
Accrued Professional Fees, Current
Accrued professional services
Cash, Cash Equivalents, and Short-term Investments, Total
Cash, Cash Equivalents, and Short-Term Investments
Cash, cash equivalents and investments in marketable securities
Schedule of Accounts Payable and Accrued Liabilities [Table Text Block]
Summary of Accrued Expenses and Other Current Liabilities
Stock, Class of Stock [Table]
Schedule Of Stock By Class [Table]
Entity Emerging Growth Company
Entity Emerging Growth Company